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1994-09-05
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Document 0844
DOCN M9480844
TI Molecular epidemiology of tuberculosis in New York City.
DT 9410
AU Friedman CR; Riley L; Kreiswirth B; Johnson WD; Manoach S; Sathianathan
K; Stoeckle MY; Cornell University Medical College, Public Health
Research; Institute, New York, N.Y.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:550 (abstract no. C-342).
Unique Identifier : AIDSLINE ASM94/94313101
AB Tuberculosis (TB) in the United States is usually due to reactivation,
but may occur as a result of recent exogenous infection. Restriction
Fragment Length Polymorphism (RFLP) analysis has been used to identify
clonal spread of recent TB infection. We used RFLP analysis to determine
the pattern of transmission of TB in New York City. We performed RFLP
analysis on TB isolates obtained during 1992 at four New York City
hospitals (TBNetwork), which had no recognized TB outbreaks. Eighty-one
isolates were analyzed. Thirteen of 81 (16%) were multi-drug resistant
(MDR), 7 (9%) were resistant to INH alone, and 58 (72%) were
drug-sensitive. Sixteen different RFLP patterns that were previously
determined to be clonal in origin were found in 36 of the 81 isolates
(44%). Forty-five distinct (non-clonal) RFLP patterns were found in the
remaining 45 isolates (56%). A clonal pattern was found in 11 of 13
(85%) MDRTB isolates and 23 of 65 (35%) non-MDR strains (p = .003,
Yates). Among isolates from patients with known HIV status, a clonal
RFLP pattern was observed in 18 of 30 (60%) HIV-seropositive patients
and 9 of 28 (32%) HIV-seronegative patients. These results indicate that
recent exogenous infection is playing a major role in the TB epidemic in
New York City, particularly in persons with HIV and MDRTB.
DE AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/TRANSMISSION
Comparative Study Drug Resistance, Microbial Hospitals, Urban Human
HIV Seronegativity HIV Seropositivity New York City/EPIDEMIOLOGY
*Restriction Fragment Length Polymorphisms
Tuberculosis/DIAGNOSIS/*EPIDEMIOLOGY/TRANSMISSION MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).